I upgraded to Windows 10 PRO 64 bit as well and see e-Sword ver 10.4 slow on opening and sometimes slow in the modules. I deselected all resources save for a few Bibles, closed and restarted and the opening is just as slow. So i checked all resources enabled again and the issue was neither slower or faster on startup.
I am running a water cooled Intel 920 on an Asus Extreme MB, 24 gigs of ram, solid state HD and AMD Radeon HD 7900 Series Cards (2) in this system. I also run Logos Gold Edition with over 5000 books. I understand the platform is different, but it opens very quickly. I use SwordSearcher and it opens very fast. It just seems that e-Sword is a bit slow.
One thing different since Windows 10 is that my profile was changed. I may have to research that issue a bit to see if it is the problem. Just thought I would throw in my 2 cents to see what folks think.
Thanks!!